Are Nonsignificant Differences Really Not Significant?

Many researchers and reviewers hesitate to publish data when treatments are not “significantly” different. Most of us were taught to use a particular probability value (usually 5% or 1%) as a critical value to test hypotheses. The term “significant” has come to be synonymous with the phrase “significant at the 5% level.” Using relatively conservative critical values prevents readers from evalua...

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Are differences in the available aromatase inhibitors and inactivators significant?

Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step in the estrogen synthesis pathway. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line t...

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Are Differences in the Available Aromatase Inhibitors and Inactivators Significant?

Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step in the estrogen synthesis pathway. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line t...

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Are Differences in the Available Aromatase Inhibitors and Inactivators Significant?

Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step in the estrogen synthesis pathway. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line t...

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Are Non-Binding Contracts Really not Worth the Paper?

This paper experimentally investigates behavior in sequential one-shot transactions which are governed by non-binding contracts. In a second, incomplete information treatment, contracts are binding for some players. While according to traditional game-theoretical analysis no trade is expected in the first treatment, full trade should result in the latter. However, we find that trade is even hig...

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Are Nonsignificant Differences Really Not Significant?

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